A SPRAVATO® Treatment Center in Indianapolis

Accentus Health TMS

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Treatment Resistant Depression is a complex and often challenging mental health condition that affects many lives across the Indianapolis metro area. Its far-reaching impact touches, not only individuals, but their families and communities as well. In the face of this prevalent concern, the mental health field has made remarkable strides, giving rise to innovative treatments, like esketamine (SPRAVATO®), that offer newfound hope and relief.

WHAT IS SPRAVATO®?

SPRAVATO® is an FDA approved prescription nasal-spray esketamine medicine, typically taken twice per week for four weeks. Esketamine can help people who have not found relief from medication:

  • Adults with treatment-resistant depression (TRD)
  • Depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions

At Accentus Health, our team of dedicated therapists takes a customized approach to care, tailoring our treatment plans to fit everyone's unique needs and circumstances. We take the time to listen and understand our patients' experiences, concerns, and goals for their mental health.

WHAT IS ESKETAMINE?

Derived from ketamine, esketamine is a more potent iteration of the original drug. The underlying hypothesis regarding its antidepressant effects revolves around its interaction with the NMDA receptor, potentially fostering the development of new nerve connections termed synapses. This heightened potency allows patients to benefit from lower doses, thereby minimizing adverse effects that may accompany treatment.

WHY CHOOSE SPRAVATO®?

In 2019, the Food and Drug Administration (FDA) greenlit the introduction of Spravato®, a nasal spray formulation containing esketamine. This marked advancement has been integrated into medical practice, particularly for patients grappling with major depressive disorder that has shown resistance to conventional antidepressant medications.

Notably, the utilization of Spravato® is subject to stringent controls, exclusively accessible through authorized medical clinics. Accentus Health is now a proud Spravato® treatment center in Indianapolis, where we provide vigilant monitoring and administration of esketamine to our patients.

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happy young woman looking in the mirror able to recognize her true self

ESKETAMINE VS. OTHER DEPRESSION TREATMENTS

One of Spravato®'s standout advantages is its potential for prompt relief. In contrast to the gradual onset of traditional antidepressants, Spravato's rapid effects may offer individuals a swift path to relief from the burdens of depression, allowing them to reclaim a sense of normalcy.

For individuals who have found limited success with conventional treatments, Spravato® offers a new avenue of hope. Its distinct mechanism and innovative delivery method make it a promising option for those who have exhausted traditional approaches, providing an opportunity for renewed well-being.

By reducing the waiting period for symptom alleviation, Spravato® allows individuals to regain control of their lives sooner. This accelerated timeline has the potential to improve the overall quality of life.

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ESKETAMINE FOR TREATMENT-RESISTANT DEPRESSION (TRD)

For individuals who have encountered challenges in finding effective relief through conventional treatments, Spravato® shines as a ray of hope, particularly for those with treatment-resistant depression.

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SPRAVATO® FOR DEPRESSION

Depression, known as major depressive disorder, is a mood disorder characterized by persistent feelings of sadness or diminished interest. This condition has the potential to disrupt an individual's routine activities. When standard antidepressant medications prove ineffective, it is called treatment-resistant depression. Esketamine can alleviate major depressive disorder symptoms in a matter of hours. This rapid relief starkly contrasts other medications for major depression, which often necessitate days to weeks before manifesting their therapeutic effects. Swift relief of this nature significantly contributes to managing depressive disorder symptoms.

WHO IS A GOOD CANDIDATE FOR SPRAVATO®?

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Your healthcare provider will work with you to determine if Spravato® is a good fit for you. Esketamine holds substantial potential for aiding an individual in resuming their daily life. Considering the specific scenarios in which Spravato® should not be taken is essential. For instance, individuals with a background of substance abuse are cautioned against this therapy, given the potential for adverse reactions.

Spravato® may not be suitable for you if:

  • You are currently pregnant, breastfeeding, or have intentions to conceive.
  • You are allergic to Spravato®'s ingredients. 
  • You have a history of blood vessel disease or cerebral bleeding.

Maintaining transparent and candid communication with your healthcare provider is crucial to facilitate their comprehensive assessment of whether Spravato® will work for you.

Potential Side Effects

Individual responses to medications can vary significantly. The associated side effects typically subside within approximately two hours following the completion of the treatment. The initial two sessions of Spravato® treatment often yield the most pronounced symptoms.

A few side effects that may arise from using Spravato® to address depression include:

  • Nausea
  • Drowsiness
  • Elevation in heart rate and blood pressure
  • Feeling inebriated
  • Headache
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SPRAVATO INSURANCE COVERAGE

SPRAVATO® INSURANCE COVERAGE

The extent of coverage for Spravato® depression treatment hinges upon factors such as the patient's condition and the insurance provider's policies. In many instances, insurance companies typically extend coverage for the nasal spray if a qualified medical professional has determined its medical necessity.

It's worth noting that esketamine (Spravato®) is frequently covered by insurance plans, including Medicare and Medicaid. This comprehensive coverage is primarily attributed to its FDA approval and substantiated track record of being effective and safe.

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Esketamine FAQ

  • How Does Esketamine Work in Treating Depression?

    Esketamine, a derivative of ketamine, operates by modulating the brain's NMDA receptors. This interaction fosters the release of certain neurotransmitters, which are crucial for mood regulation. By restoring balance to these neurotransmitters, esketamine has the potential to alleviate the symptoms of depression and offer individuals a path toward emotional well-being.

  • Is Spravato® Covered by Medicaid?

    While insurance does typically cover Spravato® for those who are eligible, the coverage under Medicaid can vary based on factors such as location and specific Medicaid plans. It's advisable to consult with your healthcare provider or insurance representative to understand the coverage options available in the Indianapolis area. You can also contact our office for additional support in navigating coverage options.

  • What is the REMS Program for Spravato®?

    REMS stands for Risk Evaluation and Mitigation Strategy. It is a program implemented by the FDA to ensure the safe use of certain medications, including Spravato®.


     The Spravato® REMS program involves various elements to minimize risks and monitor patient safety during treatment. Your healthcare provider will provide comprehensive information and guidance about the REMS program as part of your treatment process.

  • Are There Any Long-Term Effects of Esketamine Therapy?

    As with any medical intervention, the potential long-term effects of esketamine therapy are an essential consideration. Ongoing research aims to elucidate the long-term impact of esketamine treatment. Engaging in open discussions with your healthcare provider is crucial to weigh potential benefits against any long-term considerations.

  • Can I Continue My Current Medications Alongside Spravato® Treatment?

    Your healthcare provider will thoroughly assess your current medications to determine compatibility with Spravato® treatment. That said, you must be actively taking an antidepressant to be eligible for esketamine. Remember, open communication with your provider is critical for carefully managing potential interactions and adjusting dosage to optimize your treatment outcomes.

  • How Soon Can I Expect to Notice Improvements with Esketamine Therapy?

    How Soon Can I Expect to Notice Improvements with Esketamine Therapy?


    Esketamine's rapid onset of action means that some individuals may experience improvements in mood and symptoms sooner than with traditional antidepressant medications. 


    Sometimes, patients immediately experience the medication's effects, but individual responses can vary. Your healthcare provider will closely monitor your progress and work with you to tailor your treatment plan for the best possible outcome.

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