Mortality Risk Increases with Long-Term Use of Antidepressants

Long-Term Use of Antidepressants and Increased Risk

Antidepressants are commonly prescribed medications used to treat various mental health conditions such as depression and anxiety.

While they have been proven effective in managing these conditions, a recent study has uncovered a concerning association between long-term use of antidepressants and an increased risk of cardiovascular disease (CVD), cerebrovascular disease (CV), coronary heart disease (CHD), and all-cause mortality.

The study conducted an analysis of data from the UK's Biobank, a large-scale biomedical database that includes information from over 500,000 participants. The findings revealed that individuals taking antidepressants were twice as likely to develop CHD, CVD, and experience CVD-related mortality compared to those not taking these medications.

Do antidepressants shorten your life?

This discovery raises important questions and prompts further investigation into the potential risks associated with long-term antidepressant use and risk of death. While these medications can provide much-needed relief for individuals struggling with mental health conditions, it is crucial for healthcare providers and patients to have a comprehensive understanding of the potential risks and benefits.

Benefits of Treating Depression

The Link Between Antidepressant Use and Lower Risk of Hypertension and Diabetes

Did you know that treating depression can have more benefits beyond improving your mental health? Recent studies have found that antidepressant users have a lower risk of developing hypertension and diabetes compared to non-users. However, it's important to note that this may be due to the treatment of depression rather than the drugs themselves.

On the other hand, at 10 years, antidepressant use was associated with a 23% lower risk of developing hypertension and a 32% lower risk of diabetes. Source: medscape.com

Antidepressants are commonly prescribed medications used to treat depression. There are several different types of antidepressants available, but some of the most commonly prescribed include selective serotonin reuptake inhibitors (SSRIs), trazodone, mirtazapine, duloxetine, and venlafaxine. These medications work by restoring the balance of certain chemicals in the brain that play a role in mood regulation.

While the exact mechanisms behind the lower risk of hypertension and diabetes in antidepressant users are not fully understood, there are several theories. One possibility is that by alleviating depression symptoms, individuals may experience reduced stress levels, improved sleep quality, and have better overall lifestyle habits. These positive changes could contribute to a decreased risk of developing chronic conditions such as hypertension and diabetes.

Considerations and Consultation with a Healthcare Professional

If you are currently experiencing symptoms of depression, it's essential to seek help from a healthcare professional. They can assess your condition, recommend appropriate treatment options, and monitor your progress. Antidepressants may be prescribed as part of a comprehensive treatment plan, along with therapy and lifestyle modifications. 

It's important to note that while antidepressants can be effective in treating depression and reducing the risk of hypertension and diabetes, they are not suitable for everyone. Each individual's situation is unique, and a healthcare professional can help determine the most appropriate course of treatment based on factors such as the severity of symptoms, medical history, and potential interactions with other medications.

Your PCP or primary care physician may not always know about medication-free alternatives that could help you. If you are experiencing side effects with your antidepressant medication, it's essential that you ask about alternatives such as TMS therapy and Spravato. If you or someone you know is struggling with depression, don't hesitate to reach out for professional help. Remember, you're not alone, and there are effective treatments available.

Importance of Informed Conversations

In today's medical landscape, it is essential for doctors and patients to engage in informed conversations about the potential risks and benefits of long-term antidepressant use. This is particularly important because the prevalence of prescribing antidepressants has significantly increased in recent years. However, it is crucial to note that despite the widespread use of these medications, there is still a need for more studies on the long-term safety and efficacy of

antidepressants.

Empowering Patients with Information

Engaging in informed conversations will empower patients so that they gain the knowledge necessary to actively participate in their own healthcare decisions. By understanding the potential risks and benefits of long-term antidepressant use, patients can work collaboratively with their doctors to determine the most suitable treatment plan.

Additionally, informed conversations foster trust between doctors and patients. When patients feel heard and have a clear understanding of their treatment options, they are more likely to comply with prescribed regimens and experience better treatment outcomes.

Alternative Treatments for Depression

When it comes to managing depression, there is no one-size-fits-all solution. While antidepressant medications are commonly prescribed, some individuals may seek alternative treatments to decrease dependency on these drugs. Two alternative options that have gained attention in recent years are transcranial magnetic stimulation (TMS) and Spravato®.

Transcranial Magnetic Stimulation (TMS)

TMS is a non-invasive therapy that uses magnetic fields to stimulate certain areas of the brain. It is mainly targeted towards individuals who have not found relief from antidepressant medications or have experienced intolerable side effects. During a TMS session, a coil is placed on the scalp, delivering magnetic pulses to specific regions of the brain that are associated with depression. These magnetic pulses help to activate and regulate brain activity, providing relief from depressive symptoms.

Spravato®

Spravato® is an intranasal medication that is classified as a nasal spray. It contains esketamine, which is a derivative of ketamine. Unlike traditional antidepressants, Spravato® does not need to be taken orally or through injection. It must be administered in a healthcare setting under the supervision of a medical professional. It can be used in conjunction with current antidepressant medications for individuals who have not experienced satisfactory results with other treatments. Spravato® has shown promising results in reducing depressive symptoms, particularly in individuals with treatment-resistant depression.

The best part? Accentus Health TMS offers both TMS therapy as well as Spravato® treatment for their patients who reside near Indianapolis Indiana.

Combining Treatments & Wrap Up

For individuals struggling with depression, it's important to remember that alternative treatments such as TMS and Spravato® should not replace prescribed antidepressant medications without consulting a healthcare professional. These alternative treatments can be used as adjunct therapies to enhance the effects of existing medications. Combining treatments may offer a more comprehensive approach to managing depression and improving overall well-being. It is crucial to work closely with a medical professional to determine the most appropriate course of treatment for each individual's unique needs.

If you or someone you love is suffering from depression and has been on multiple medications but aren't seeing the results that they expected, please contact our local mental health clinic. We know what it's like to deal with the medication side-effects and offer state of the art treatments that can help. Call or use our contact form online and we'll be in touch.

Local to Indianapolis? Call us to discuss your options. (317) 721-4169